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Joseph S. Alpert, MD

  • Professor of Medicine
  • Head, Department of Medicine
  • University of Arizona Health Science Center
  • Tucson, Arizona

Anterior ethmoidal branch of the naso Sphenoid sinuses develop in the body of the ciliary nerve anxiety chat room 25 mg zoloft sale, supplying the upper part of sphenoid bone anxiety 9 months pregnant purchase online zoloft. The two sinuses are unequally the lateral wall and the septum divided by a septum anxiety knot in stomach discount 50mg zoloft. Sphenopalatine nerves (long and short) bipolar depression helpline zoloft 25mg mastercard, Superiorly the sinus is related to the frontal branches from the sphenopalatine gang lobe and olfac to ry tracts. The Sympathetic Supply fibres in the greater superficial petrosal nerve the preganglionic fibres arise from the first end in the sphenopalatine ganglion. Postgang and second thoracic segments of the spinal lionic fibres arise from this ganglion and both cord and end in the corresponding sympathe sympathetic and parasympathetic fibres are tic ganglia. These fibres ascend in the cervical distributed through the sphenopalatine nerves sympathetic chain to synapse in the superior to the nasal mucosa. Submandibular lymph nodes collect lymph from Parasympathetic Supply the external and anterior parts of the nasal the preganglionic fibres arise in the superior cavity. Airconditioning and humidification: the system and serves the following important highly vascular mucosa of the nose main functions. Respira to ry passage: Normally, breathing thus, prevents the delicate mucosa of the takes place through the nose. The inspired respira to ry tract from any damage due to air passes upwards in a narrow stream temperature variations. The humidified air medial to the middle turbinate and then is necessary for proper functioning and downwards and backwards in the form of integrity of the ciliated epithelium. Vocal resonance: the nose and paranasal sinuses serve as vocal resona to rs and nasal restricted to the central part of the nasal passages are concerned with production of chambers. Thus obstructive lesion in this region is obstructions of the nasopharynx and nose important, as this disturbs the air flow. Vibrissae (nasal hair) in the nasal include sneezing, and nasopulmonary, vestibule arrest large particulate matter nasobronchial and olfac to ry reflexes. Olfac to ry are deposited on the mucus blanket reflexes influence salivary, gastric and which covers the nasal mucosa. The nasal cavity serves as an outlet for lacrimal lysozymes having antibacterial proper and sinus secretions. This sensa is carried by the ciliary movements tion plays the most important role in posteriorly to the oropharynx, to be behaviour and reflex responses of lower swallowed. Normally the olfac to ry sense smells nasal cavity and adjacent area of superior one olfact. The Olfac to metry gives information about the olfac to ry cells are distributed in the olfac to ry following. Qualitative Olfac to metry Parosmia the olfac to ry sense is assessed by taking a It is a qualitative change. The following primary odours are usually It may occur in the following conditions: tested: i. Obstructive lesions in the nose and Quantitative Olfac to metry nasopharynx the measurement of olfac to ry sense can be ii. As is evident from the appearance of the different animals, nature has provided Exaggeration of the olfac to ry sensitivity is nose at such a place and in such a form as the termed hyperosmia and it occurs with the concerned species needs it for its survival. Pregnancy, hunger, strychnine poison anterior nares are placed high up on the snout, ing so that the animal may breathe when under iii. The temperature buffers: It is regarded that has nostrils that can be closed under water. Probably, sinus formation in the cranial troglodytes) the nose is very short in relation bones helps in reducing the weight of the to snout. The following symp to ms may be the common conditions of the nose and para present alone or in combination depending nasal sinuses which result in nasal obstruction upon the disease process. Mucoid discharge is associated with a his to ry of breathing through usually a feature of allergic rhinitis while mucopurulent discharge occurs in infective the mouth, and dryness of the throat due to lack of the humidifying action of the nose. Purulent discharge is a feature of atrophic Facial Pain and Headache rhinitis, foreign bodies in the nose, furuncu losis and long-standing sinusitis. Nasal and paranasal sinuses are frequently Blood-stained nasal discharge usually blamed for headaches and facial pain. Pain indicates an underlying malignant process, due to involvement of different sinuses has foreign body or nonhealing granulomas, etc. Nasal Obstruction Frontal Sinus Headache Obstruction to the passage of air through the Pain due to inflammation of the frontal sinus nose may be unilateral or bilateral. The pain Common Symp to ms of Nasal and Paranasal Sinus Diseases 159 is more during early hours of the day and coming in to the oropharynx causing various subsides or diminishes in intensity by after pharyngeal symp to ms. Pain due to the involvement of the maxillary Speech Defect sinus is more over the maxillary region. Ethmoid Disorders of the nose and nasal sinuses may sinus pain usually occurs along sides of the result in loss of the resonating function and nose or in the orbits. Sphenoid Sinus Headache Symp to ms due to Extension of the the pain is referred to the vertex or occiput Disease to the Adjacent Regions or may be present behind the eyes. Facial pain due to other nasal and para Diseases of the nose or paranasal sinuses may nasal lesions may occur as in furunculosis, involve adjacent structures like the orbit, syphilis, due to nerve infiltration as in sinus cranial cavity, cavernous sinus, etc. Epistaxis Sneezing Bleeding from the nose may be unilateral or Sneezing is the normal nasal reflex to clear bilateral and may be due to a variety of lesions secretion from the nose and is of great impor of the nose, paranasal sinuses and the tance in young children who have yet not nasopharynx. The sensory side of the Various olfac to ry derangements have already reflex is transmitted through the trigeminal been discussed. Normally the secretions from the nose and nasopharynx are carried to the oropharynx by Snoring the mucociliary mechanism of the nose, where from these are swallowed. Many times the Abnormal sound produced through nose patient complains of excessive nasal discharge during sleep is called snoring. It has many 160 Textbook of Ear, Nose and Throat Diseases causes like adenoids in children or polypi or pharynx which results in collapse of airway growth in nose, to o much hypertrophied due to suction effect and as respira to ry effort turbinates, oedema to us mucosa of nose or soft increases, the resulting apnoea causes prog palate. While the treatment of all pathological ressive asphyxia, which results in arousal from conditions relieves snoring, but some people sleep, with res to ration of patency and airflow. Under local anaesthesia, a small glossia, retrognathia in a minority of patients, needle connected to a radio-frequency and a subtle reduction in airway size in a genera to r is inserted in to the soft palate majority of patients. The be usually demonstrated by imaging and radio-frequency energy is directed through acoustic reflection techniques. Over few weeks, the In central sleep apnoea there is transient body naturally reabsorbs some of the loose abolition of central drive to ventila to ry musc tissue thus relieving snoring. Mixed apnoea is a combination of failure of central control and Normal respiration requires air to be displaced upper airway obstruction. Crucial in this the narrowing of airway during sleep inevit process is the ability of upper airway to per ably results in snoring. In most pateints mit the unimpeded transport of air to tracheo snoring antedates the development of obstruc bronchial tree. The nocturnal asphyxia and frequent the supralaryngeal airway is most susceptible arousal from sleep lead to day-time sleepiness, to obstruction during the skeletal muscle intellectual impairment, memory loss, hypo to nicity associated with sleep. Other Manifestations Sleep apnoea is divided in to obstructive, central and mixed types. Common Symp to ms of Nasal and Paranasal Sinus Diseases 161 the clinical manifestations are aggravated 8. Management Treatment Investigations the investiga to ry part includes: It can be medical or surgical. Transcutaneous moni to ring of (oxygen) O2 severely affected patients who are unsuitable saturation during sleep. Radiology for identification of adenoid obstruction of nasopharynx and to nsillar obstruction of oropharynx. A dislocated anterior end of the general examination of the face and nose, septum may be visible. The difference on the two sides is an indication of nasal obs this is done to detect any deformity, asym truction. Dep ression or deviation of the nasal bridge due to ment, on expiration, of a cot to n wick held near the nostrils also gives an idea about the degree injury or disease may be present.

Selkoe mood disorder meds for kids 50mg zoloft with mastercard, projected relative sea-level rise and recent his to rical reconstruction of shoreline and S mood disorder 8 year old zoloft 25mg with mastercard. Ishii depression vegetative symptoms cheap 100mg zoloft overnight delivery, 2012: Human-induced global ocean warming on to the ecosystem-based management seascape mood disorder etiology discount 25 mg zoloft otc. Vuorinen, 2011: Time-varying parameter analysis of the Baltic the Greater Caribbean Region 1996-2006. Vasta, 1999: Emerging marine diseases-climate links and anthropogenic Bulletin of Marine Science, 87(4), 767-794. Crespo, 2008: Spatio-temporal upwelling trends along the Canary Upwelling Samuel, 2002: Climate warming and disease risks for terrestrial and marine 30 System (1967-2006). Bloch, 2009: Large bio-geographical shifts in the north-eastern Atlantic Ohman, K. Sheppard, 2008: Climate warming, Ocean: from the subpolar gyre, via plank to n, to blue whiting and pilot whales. Menge, 2004: Upwelling-driven nearshore hypoxia signals ecosystem of Pacific to p preda to rs in a changing climate. White, 2010: An and composition in the Northwest Atlantic: a comparison of results obtained assessment of climate change impacts and adaptation for the Torres Strait by continuous plank to n recorder sampling and colour satellite imagery. S to tt, 2007: Understanding and attributing climate among fishing, ocean warming, and ocean acidification in a marine system change. Working Group I to the Fourth Assessment Report of the Intergovernmental Gruber, N. Levin, 2004: Global distribution of naturally occurring marine cumulative impacts in ecosystem-based management through ocean zoning. Deep-Sea Research Part I: Oceanographic Ocean & Coastal Management, 51(3), 203-211. Jarre, 2004: Changes in the northern Benguela Williams, 2012: the geological record of ocean acidification. Progress change detected by Argo and its implication for hydrological cycle intensification. Ridgway, 2008: Wind forced low frequency primary productivity change and fishing impacts on the Central North Pacific variability of the East Australia Current. Geophysical Research Letters, 35(8), ecosystem and Hawaii-based pelagic longline fishery. Roughgarden, 2003: Climate change, distributions in coastal waters of the northern Arabian Sea, August, 1995. Shifting base-lines, declining coral cover, and the erosion of reef resilience: Hjort, J. Bruno, 2010: the impact of climate change on the North Pacific Ocean, 2003-2008 [McKinnell, S. Uiblein, 2012: Effects of interactions between fish populations on Iglesias-Prie to , N. Climate-driven trends and ecological implications of event-scale upwelling in Hoegh-Guldberg, O. Zooplank to n species composition is linked to ocean transport in the Northern Allen, M. Fukuwaka, 2011: Pacific salmon abundance trends and climate Caldwell, 2011: Mitigating local causes of ocean acidification with existing change. In: Climate Change and the Oceans: Gauging the Legal and Policy walleye pollock (Theragra chalcogramma) in the northwestern Pacific. Tsyban, 2011: A persistent oxygen anomaly reveals the fate of spilled methane in the and S. Peng, 2004: A global ocean carbon clima to logy: Panel on Climate Change [Watson, R. Stiansen, 2012: Changes in Barents Sea fish biodiversity hotspots in the Benguela Current Large Marine ecosystem state, 1970-2009: climate fluctuations, human impact, and trophic Ecosystem: relevance in the light of global changes. Opdyke, to Mediterranean and nearby Atlantic sea level variability under different 1999: Geochemical consequences of increased atmospheric carbon dioxide climate change scenarios. Turner, 1996: Effects of climate change on hypoxia Marine Ecology Progress Series, 436, 207-218. Oceans: Gauging the Legal and Policy Currents in the Asia Pacific and Beyond Laffoley, D. Journal of Physical 2011: Long-term shifts in abundance and distribution of a temperate fish Oceanography, 9(2), 446. Cai, 2002: Trends of sea level rise in the South China Sea during Biogeography, 20(1), 58-72. Zhang, 2011: Assessment of coral bleaching effects on export production in the open ocean. Global Biogeochemical Cycles, using symbiotic zooxanthellae density and satellite remote sensing data in the 14(4), 1231-1246. Xu, 2005: Environmental changes and the Pacific warm pool and divergence: temporal and zonal variations on the equa to r responses of the ecosystems of the Yellow Sea during 1976-2000. Young, 2011: Vulnerability of open oceans food webs in the tropical of Applied & Environmental Biology, 17(5), 615-623. 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Consider delegating tasks to trusted friends and/or family members to help, knowing that: fi Calls to financial institutions do not have to be made immediately nor all at once. However, you should also contact Social Security within a reasonable timeframe to see if you qualify for the small death benefit they offer. Your funeral direc to r can provide additional information and coordinate this upon request. The deceased may have left a letter of instructions and/or a Last Will and Testament. An execu to r will be named within the Will who is responsible for coordinating how the estate is settled. The cost can be fairly minimal compared to the stress involved trying to navigate the legal steps on your own. There may be financial arrangements already made for paying for the funeral and/or burial such as a life insurance policy. While each person experiences grief differently, you may find comfort knowing that others share similar loss responses. Path to Healing Each person has an individual style of coping with painful experiences. Moving Through Grief For a while, your grief may feel intensely personal and confusing. In doing the work of grief, you are moving to ward a renewed sense of meaning and purpose in life. Contact Us EvergreenHealth Hospice is here to offer compassionate support and information to help guide you through your time of loss. For more information about our grief and bereavement services, please speak with a member of your Hospice care team or call EvergreenHealth Hospice Bereavement Services at 425. We will share with them that a gift has been made; however, we will never divulge the amount given. Grateful patients and their family may wish to acknowledge the quality care they received, but please remember that staff members cannot accept gifts. Instead, you may acknowledge your professional team members by a commemorative gift in their honor. Ways to Give We appreciate your interest in supporting the essential goals of the EvergreenHealth Foundation. Gifts can be made in the form of cash, gift of securities, real estate, or personal property. The Evergreen Legacy Society exists to honor those individuals who have chosen to leave a lasting legacy for future generations through a bequest in your will, living trust, a gift of life insurance; or through a gift plan that provides you or a loved one with life income. You can make a contribution over the phone and charge your gift to your credit card. You may also print the Donation Form (pdf) and mail the form along with your check or credit card information to the above address. Fax Please print the online Donation Form (pdf) and fax the form with your credit card information to 425. EvergreenHealth Foundation is registered with the Internal Revenue Service as a non-profit 501(c)(3) organization. The Foundation is registered with King County and the State of Washing to n to solicit funds. Most agencies are licensed and bonded with the state of Washing to n; however, for your protection, ask for verification. Strain tea to remove tea leaves and add only 1 pint tea to a large pot; then add fruit. If the fruit paste is not working (no bowel movements), then increase the amount of fruit paste each day. If the fruit paste induces very loose s to ols, cut down on the amount of fruit paste intake; consider taking it every other day. This to ol for tracking symp to ms can help explain what symp to ms you are experiencing, how often and how severe they are. List your symp to ms and rank them between 1 (affecting you the least) and 10 (affecting you the most). Symp to ms may include bone ache, constipation, depression, diarrhea, dizziness, fatigue, fever, headache, incontinence, swelling of the arms or legs, memory loss, mouth sores, muscle ache, nausea, no appetite, numbness or tingling, generalized pain, urinary pain, urinary urgency, weight gain, weight loss, etc. List the symp to ms you are experiencing, enter the date in the Date column, and rank the symp to m from 1 to 10. Never leave heaters on when you leave the house or go to bed, and keep children well away from them. S to p where you are, drop to the ground, and roll over and over to smother the flames. If you get caught in smoke, the cleanest air will be several inches off the floor. What to Do During an Earthquake fi If you are inside when the shaking starts, stay inside and take cover under a desk or table and hold on or sit against an inside wall and cover your head and neck. What to do if Flooding Occurs fi Disconnect electrical appliances and do not to uch electrical equipment if you are wet or standing in water. Page 62 of 69 Plan for Family Communication fi Make sure everyone carries a copy of this information in his/her backpack, purse, or wallet. Text messages may also save and then send au to matically when capacity becomes a v a i l a b l. In a disaster, it may be easier to make a long distance phone call than to call across to wn because local phone lines can be jammed. Discuss these plans with children, and let them know who could pick them up in an emergency. Make sure your household members with phones are signed up for alerts and warnings from their school, workplace, and/or local government. Family Contact Information Name: #: #: Media: Email: medical or other information: Name: #: #: Media: Email: medical or other information: Page 63 of 69 Name: #: #: Media: Email: medical or other information: Name: #: #: Media: Email: medical or other information: Name: #: #: Media: Email: medical or other information: Name: #: #: Media: Email: medical or other information: Name: #: #: Media: Email: medical or other information: Page 64 of 69 Prepare for Evacuation Make a plan to day. Your family may not be to gether if a disaster strikes, so it is important to know which types of disasters could affect your area. Evacuation Checklist fi Unplug electrical equipment except for freezers and refrigera to rs.

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In addition the rectal and vesicle branches of the internal iliac artery may simulate the uterine artery mood disorder questionnaire age range 25 mg zoloft fast delivery. The optimum occlusion of blood supply to the fibroid is achieved when uterine artery is embolised at the level of perforating branches anxiety black eyed peas 100 mg zoloft overnight delivery. Proximal occlusion of larger arteries with coils or similar agents is not expected to provide clinical success and if the procedure needs to be repeated they will prevent re-entry of micro catheter (Spies et al depression quiz free buy discount zoloft 100mg on line. At present anxiety panic attack zoloft 50mg overnight delivery, distal embolization can best be accomplished with particulate agents suspended in contrast solution. The main procedure involves catheter placement in femoral artery via single groin puncture. A 5-F angiographic catheter (3-French = 1mm diameter) is placed via the groin and advanced over the aortic bifurcation to the contralateral internal iliac artery, and digital angiography is done to identify the origin of the uterine artery. There is often a great deal of to rtuosity at the origin, and catheter induced spasm is common. This can be avoided to some extent by 178 Hysterec to my coaxial placement of 3-F micro-catheter. After successful catheterization of uterine vessels, solution of polyvinyl alcohol particles mixed with sterile saline and iodinated contrast medium is injected in to the vascular lumen. The particles wedge in the vessels and cannot travel to any other parts of the body. The embolization is continued until there is nearly complete blockage of flow in the vessel. If necessary, after embolization of the artery with particles pledgets of an absorbable gelatin sponge may be placed via catheter to complete the embolization. The 5-French catheter is then formed in to a loop, and the catheter is placed in to the ipsilateral internal iliac artery; the embolization procedure is then repeated in the right uterine artery. Another postembolization angiogram is taken to confirm complete blockade and all catheters are then removed. Additional pain medication may include paracetamol (acetaminophen) which also has an antipyretic effect. Pain control, particularly in the first twelve hours, is important as some patients develop pelvic pain of severe intensity. Patient controlled analgesia with use of intravenous opioids morphine, meperidine, hydrocodone, or fentanyl has been used effectively in most centers (Ryan et al. Postprocedural pain cannot be predicted from baseline uterine or fibroid volume and the severity of pain experienced cannot be used to predict outcome. It varies significantly among patients and consists of an early ischemia-related component followed by pain that is modulated by the inflamma to ry response to tissue necrosis. Pain levels peak within the first 6-8 hours and need to be addressed by a continuous and potent analgesia regimen. Pain may be constant, crampy or in waves, can be quite severe and is unrelated to the size, location or number of fibroids. Pain medication should be started after catheterization of the uterine artery and not after the procedure. Alternatives to intravenous opioids for pain control are spinal or epidural anesthesia. However, these analgesic regimens require the help of anesthesiologists, leading to a technically more complex scenario (Roth et al. Nausea is a common side effect of the embolization procedure and/or the medications used for pain control and hence there is a significant role for preoperatively administered antiemetic agent. During bedrest the patient should receive standard prophylaxis against deep vein thrombosis. Oral anti-inflamma to ry agents and narcotics are commonly used for several days after the procedure (usually 7-10 days). In the first pos to perative week, approximately 10 to 15 percent of patients experience postembolization syndrome which is characterized by nausea, and/or vomiting, malaise, low grade fever, pain abdomen and elevated white blood count. The pain is due to ischemia induced by vascular occlusion and Is Embolization Equal to Hysterec to my in Treating Uterine Fibroidsfi Most complications were minor and occurred during the first 3 months after the procedure. This complication is more frequently seen in patients with submucosal fibroids or intramural fibroids with a submucosal component. Expulsion most often occurs within 6 months after the procedure, but there are reports of this event after a period of time as long as 4 years (Marret et al. In most cases, the infarcted fibroid is expelled spontaneously, and no additional treatment is necessary. Hysteroscopic resection or dilation and curettage is reserved for cases in which the fibroid is only partially infarcted and remains firmly attached to the uterine wall due to the increased risk of secondary infection (Marret et al. When uncomplicated, fibroid expulsion can res to re the uterine ana to my to nearer normal more rapidly than otherwise. In a minority of cases, however, retention of necrotic fibroid tissue may result in chronic vaginal discharge due to shedding of fibroid material in to the endometrial cavity. This condition can be treated effectively by hysteroscopic resection of the necrotic fibroid material (Ogliari et al. If left untreated or refrac to ry to antibiotics, uterine infection can lead to sepsis and the need for emergency hysterec to my. Sepsis is suspected when relatively high grade fever persists beyond the 24 to 48 hours typical of post embolization syndrome. There is also evidence that certain pre existing conditions, such as a coexistent adnexal pathology (Nikolic et al. If we assume that all these deaths were related to the procedure, the mortality risk would be 0. An ischemic injury to the uterus of such severity necessitating hysterec to my is required in less than 1% of patients. Postembolisation amenorrhea is usually limited to a few cycles and is not considered a major complication. There have been anecdotal reports of ovarian failure in younger women (Pron et al. Furthermore, loss of ovarian perfusion, as demonstrated by sonographic assessment, directly after treatment in a substantial number of patients has been observed (Tulandi et al. In addition, there are some risks that are associated with any form of angiographic procedure, such as hema to ma formation or infection at the catheter insertion site in the groin, contrast media reactions, and damage to blood vessels. There are few case reports of unintended embolization resulting in pelvic organ damage. With opera to r experience and limiting fluoroscopy time, the use of magnified and oblique views, non-pulsed fluoroscopy and road-mapping, the absorbed ovarian dose may be minimized (Andrews & Brown 2000; Binkert et al. Furthermore, major complications are thrombosis, septicaemia, and emergency myomec to my/hysterec to my (Spies, 2002, 2002b). More often are minor complications like minor infections, haema to ma requiring treatment, drug reaction, permanent amenorrhoea, retention of urine requiring catheterisation, and fibroid expulsion (Marret et al. Large case series with less than 2 years of follow up reported rates of treatment failure, defined as the need for subsequent interventions, ranging from 5. First, since the procedure causes fibroid shrinkage but preserves normal uterine tissue, it is possible that new fibroids will develop and symp to ms recur. A prospective study using transvaginal ultrasound reported appearance of new fibroids in 8. Incomplete fibroid infarction is most often related to technical aspects of the procedure such as the presence of collateral blood supply to the fibroids (usually from the ovarian arteries) or difficulties in cannulating both uterine arteries as a result of ana to mical variation or arterial spasm. Patients are reassured, minor problems such as minimally increased temperature, onset of minor vaginal bleeding etc. Some centres with an outpatient interventional radiology clinic may also see the patient at 4 weeks for a regular check-up. Improvement in clinical symp to ms is generally seen three months after the procedure.