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Sergei Rachmaninoff owned two New York Steinways in his Beverly Hills home and one New York D in his New York home but chose a Hamburg D for his Villa Senar in Switzerland hair loss gastric bypass generic propecia 1mg. The differences between New York Steinways and Hamburg Steinways are less noticeable today although some objective differences are well known hair loss in men enhancement order propecia with mastercard. At present 2 hair loss 5 month old baby order propecia now, 500 Steinway pianos are built in New York every year and 1 curezone hair loss 1 mg propecia otc, 500 are built in Hamburg. The market is loosely divided into two sales areas, New York Steinway supply North and South America with their pianos and Hamburg Steinway supply their pianos to the rest of the world. At all main Steinway showrooms across the world pianos can be ordered from both factories. New York and Hamburg factories exchange parts and craftsmanship and Steinway parts from both factories come from the same places. Canadian maple is used for the rim and soundboards are made from Sitka spruce from Alaska. Recently Steinway has taken over its suppliers of keyboards and iron frames in order to maintain quality. William Steinway had engaged the Russian pianist Anton Rubinstein to play an American concert tour in 1872, with 215 concerts in 239 days. Later Ignacy Jan Paderewski played 107 concerts in 117 days travelling through America with his own railway carriage and Steinway concert grand piano. According to Steinway & Sons, 98% of piano soloists chose to play publicly on a Steinway during the 2005-2006 North American Concert season. They are expected to perform exclusively on a Steinway piano whenever one is available. The Gina Bachauer International Piano Competition and the Van Cliburn International Piano Competition are sponsored by Steinway and use Steinway pianos exclusively. Glenn Gould played his own Steinway D in most of his studio recordings of music by Bach, Mozart and Schoenberg. A Steinway piano has about 200 strings, one or two strings for each note in the bass section and three strings for each note in the middle and descant sections. Every Steinway is made to the same technical standards yet every Steinway ends up being slightly different from every other in responsiveness to touch and in delivery of tonal nuance. There are 115 registered Steinway patents including patents relating to the repetition action, the metallic frame for upright and grand pianos, improvements in soundboards, reinforced soundboard ribs, the sostenuto pedal, silent keyboard mechanisms, the grand piano case (which is still the current design), wood bending machines for the rim, layered soundboard bridges, the treble bell frame for a grand piano, an upright piano case with 388 swinging panel, a string frame and a sliding lid for upright pianos, and piano key levelling. He was a pupil of Ignaz Moscheles in Leipzig and Karl Reinecke at Leipzig Conservatory. He later studied with Theodore Kullak in Berlin and became a pupil of Liszt in 1874. As you know, the master took a complete musical knowledge for granted and it was, of course, not for that that I went to him; but in regard to his art-ethical views, to freedom of conception and interpretation, to distinguishing between the letter and the spirit I learned more than ever before or since. I think that in my case, this last mentioned distinction was perhaps the strongest point of his teaching. He did remember me in the kindest possible manner (could he ever be other than kind Of Liszt, the executive and creative musician, the world is no longer in complete ignorance, though there is much, very much indeed, that the world still has to learn of that side of the master, but the man Liszt His breadth of learning; his unparalleled tact; his Christ-like goodness and kindness; his lenity [sic] with imperfections; his encouraging attitude towards his students; how can the world ever know that side of him He studied composition with Bruckner, and piano with Leschetizsky and Anton Door (a pupil of Czerny) before coming to Liszt. He composed vocal and piano pieces, made piano arrangements of orchestral works by Liszt, Beethoven and Bruckner, and made piano transcriptions of organ compositions by Frescobaldi and Buxtehude. His transcriptions were played in his day by Cortot, Friedman, Reisenauer and Sauer. The treble strings produce the highest notes and are found at the right hand end of the piano. When the strings are new they are very shiny like polished brass but they soon tarnish and become dull. When bass strings are very old the copper winding may become clogged with dirt and the tone may become dead. This means that the combined tension can be up to 20 tonnes in a concert grand piano. Some old pianos have a wooden frame which tends to move under the tension of the strings causing tuning instability. The bottom end of the string goes over a hitch pin and the top end of the string goes through a hole in the tuning pin and is wound round three or four times. The piano is tuned by adjusting the tension on each string which is done by winding the tuning pin tighter or looser. Chopin specifically marks it in the opening of his Nocturne in B flat minor opus 9 no. The opening notes of the phrase may start very sofly to enhance the effect and the closing notes of the phrase may, similarly, become very soft. Placement of accents where they do not normally exist is called syncopation and Beethoven and Brahms are two composers noted for their effective use of syncopation. The beat normally accented may be softened so that the syncopation can be brought out into relief. Syncopated pedalling Syncopated pedalling refers to the usual method of legato pedalling where the sustaining pedal is changed slightly after a note or chord to achieve a true legato effect. He was brought to Liszt in the summer of 1855 as a thirteen year old wunderkind by his father Aloys Tausig who was also his first teacher. On 21 July 1855, at a soiree at the Altenburg, Tausig played some pieces and he and his father Aloys, a respected piano teacher, were presented to Hans von Bulow and various members of the Weimar school. In 1864 Tausig married the pianist Serafina Vrabely, from whom he was later divorced. In 1865 he settled in Berlin where he founded a School for Advanced Piano Playing.

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Kaaja (2003) prospectively followed up 970 pregnancies in women with epilepsy at a single maternity clinic hair loss in men 21 cheap propecia 1 mg with mastercard. The occurrence of major malformations was associated with various anticonvulsants hair loss guinea pigs buy discount propecia, but not with carbamazepine monotherapy hair loss cure laser cheap propecia 5 mg with amex. The teratogenic effect of carbamazepine seems to be associated with noticeably reduced activity of the enzyme hair loss treatments that really work buy propecia canada, epoxide hydrolase. On the contrary, in 2 a study by Gaily (2004), the intelligence of 182 children of mothers with epilepsy (study group) and 141 control children was tested in a blinded setting at preschool or school age. Data on maternal antiepileptic treatment and seizures during pregnancy were gathered prospectively. Of these children, 107 were exposed to antiepileptic monotherapy, among them 86 to carbamazepine. The median maternal doses and blood levels of carbamazepine during the second half of pregnancy were 600 mg and 26 mol/l. The authors concluded that carbamazepine monotherapy with maternal serum levels within the reference range does not impair intelligence in prenatally exposed offspring. Exposures to polytherapy and to another drug (valproate) during pregnancy were associated with significantly reduced verbal intelligence. Carbamazepine may be used in pregnancy to treat epilepsy, keeping in mind the risks mentioned. The drug concentration should be monitored regularly, and the daily dose kept as low as can be justified therapeutically. Liver and kidney function, as well as hematological parameters, should be checked regularly. However, as an additional preventive measure, a detailed ultrasound diag nosis should be conducted in the second trimester as well as an fetopro tein determination in the maternal serum around week 16, especially to detect neural tube defects. To decrease the risk of coagulation disturbances in the fetus and newborn, the newborn should receive 1mg of vitamin K (preferably intramuscularly) at birth and 1mg orally every 3 days in the first 2 weeks of life (see also section 2. It seems to facilitate the transfer of glucose in the brain and, under experimen tal conditions, it raises the seizure threshold. Toxicology There are only a few reports of ethosuximide therapy during preg nancy. No typical pattern of birth defects has been observed in the infants of 57 treated women (Lindhout 1992). In a series of 18 fetuses exposed during the first trimester, there were no birth defects (Rosa 1993, cited in Briggs 2005). Although the available reports are in no way sufficient for a differentiated risk assessment, there does not seem to be a teratogenic risk comparable to the other anti convulsants. There is a report of neonatal hemorrhage following in utero exposure to ethosuximide, indicating a vitamin K antagonistic potential (Speidel 1974). There is insufficient experience with the other succinimides, mesux imide and phensuccimide, to assess their risks in pregnancy. Mesuximide and phensuccimide are less well studied, and are therefore not recommended. However, detailed ultrasound diagnosis around week 20 should con firm normal development of the fetus. To decrease the risk of coagulation disturbances in the fetus and new born, the newborn should receive 1mg of vitamin K (preferably intramuscu larly) at birth and 1mg orally every 3 days in the first 2 weeks of life (see also section 2. Currently, this drug is no longer used because of its numerous side effects and because of the availability of better medications. Experience is lim ited, depending primarily on 36 documented pregnancies in 9 fami lies, and suggesting a comparatively high teratogenic risk. Oxazolidine anticonvulsants are contraindicated in pregnancy because better-tolerated anticonvulsants are available. Neverthe less, when there has been exposure, termination of pregnancy is not indicated. However, an expanded prenatal diagnosis with a detailed fetal ultrasound during the second trimester should be conducted to identify any major distur bances of structural development. These probably achieve their anticonvulsant effect by stabilizing the neuron membranes. Primidone is converted to the metabolites phenobarbital and phenylethylmalonamide, which have an anticonvulsant action. Because the indications, effectiveness, half-lives, and undesirable side effects of primidone and phenobarbital in pregnancy are similar, only phenobarbital will be described extensively. Barbexaclone is phenobarbital combined with levopropylhexedrine, a psychostimulant that can counteract sedation. Phenobarbital and primidone are very effective in focal epilepsy and grand-mal seizures. Phenobarbital has been used as a sedative and anticonvulsant since the beginning of the twentieth century (Hauptmann 1912). About 25% is excreted unchanged via the kidney, and the remainder is excreted after oxidative metab olism. Phenobarbital reaches the fetus quickly, and results in an increase in fetal liver enzyme activity, especially in the perinatal period. Such applies to the glucuronidating enzymes that are responsible for the excretion of bilirubin (Tavoloni 1983). According to studies from the same authors, cardiovascular birth defects occurred somewhat more frequently than expected when the less common barbiturates were used. A possible association with cardiovascular defects was discussed, but a distinctive pattern was not found (Rosa 1993, cited in Briggs 2005). In two studies, malformation rates of about 5% were observed for phenobarbital monotherapy (Canger 1999, Kaneko 1999). A syn drome of facial dysmorphia, characteristic also for other anticonvul sants, was described in 15% of 46 children exposed to phenobarbital: epicanthal folds, hypertelorism, broad, flat nasal bridge, upturned nasal tip, and wide prominent lips. Distal digital hypoplasia was observed in 24% of the children, and developmental delay in 3 of the 16 children that were examined in later life (Jones 1992). In the 1970s, these features, including intrauterine and postnatal growth retardation, were described by some authors in pregnant patients treated with phenobarbital during pregnancy. The clinical features were similar to those seen with in utero exposure to both phenytoin and alcohol. The authors felt that it should not be classi fied as a separate syndrome (Seip 1976). There have been reports that a combination of phenobarbital and caffeine may increase the malformation rate: Samren (1999) reported five infants with major malformations exposed to this combination, but did not draw any conclusion on the role of caffeine. Phenobarbital therapy can affect the metabolism of steroids, vita min D, and vitamin K, and, at least theoretically, can cause hypocal cemia and coagulation disturbances in the newborn (Kaaja 2002, Friis 1977). Probably, it is more efficient to administer vitamin K to the neonate (Hey 1999, Howe 1999, Eller 1997, Malone 1997). A primidone embry opathy has been suggested with hirsute foreheads, thick nasal roots, anteverted nostrils, a long philtrum, straight thin upper lip, distal digital hypoplasia, intrauterine growth restriction, and an increased risk for psychomotor retardation and heart defects (Gustavson 1985, 2 Rudd 1979). In contrast to long-term anticonvulsant use, single doses of barbi turates (such as in painkillers or as part of narcosis) have never been associated with being teratogenic. High doses, administered shortly before delivery, can result in neonatal respira tory depression. In the study by Adams (2004), children in utero exposed to phenobarbital monotherapy had scores on the general, verbal, and non-verbal indices of neurodevelopment 10 to 14 points lower than controls. On the contrary, Dean (2002) found that infants exposed in utero to phenobarbital monotherapy had not more often devel opmental delay than controls. Van der Pol (1991) reported that the cognitive development of children who had been exposed in utero to phenobarbital alone, or in combination with carbamazepine, was significantly impaired in comparison with children of non-epileptic mothers.

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Syndromes

  • Rapid heartbeat
  • Hypersplenism
  • Infection (a slight risk any time the skin is broken)
  • The time it was swallowed
  • Birth defects of the lower spine
  • Heart attack
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  • Decreased visual acuity
  • Adults: 16 to 125